0231 Slow Wave Activity During Restricted Sleep Buffers Against Negative Effects on Daytime Positive Emotion in Pre-pubertal Children

Abstract Introduction Increased slow-wave activity (SWA) following sleep loss is a well-established physiological marker of increased pressure. Recent research found SWA changes in response to partially accounted for next-day decrements positive affect (Finan et al., 2015; 2017). To our knowledge, however, this line inquiry has been limited adults. Recently, we greater during night healthy predicted emotion among pre-pubertal children (Rech 2022). Here, explored whether the second two nights partial restriction emotional responses same cohort. Methods N=24 healthy, unmedicated (7 11 years) completed baseline assessment and one at-home PSG monitoring (10 hours bed). Ten days later, (7-hour opportunity) followed by in-lab with (6-hour opportunity). The next day, an where they provided arousal valence ratings affective images from International Affective Picture System (IAPS). Results Controlling age total time first night, hierarchical multiple regression analyses examined if N3 frontal, central, occipital regions IAPS ratings. In separate models, both F(1,20)=8.535, p=.008, density, F(1,20)=12.313, p=.002, (where lower scores indicated more valence). Conclusion While preliminary, findings indicate relationships between “rebound” after functioning children. Findings suggest that, prior pubertal transition, trait-based differences homeostatic pressure recovery might alter responding, potentially influencing risk later mood disturbances. Support (if any) This was supported NIMH grant #R21MH099351 awarded C.A.A.